![van der heuvel human brain mapping diffusion van der heuvel human brain mapping diffusion](https://iiif.elifesciences.org/lax/60136%2Felife-60136-fig1-v2.tif/full/1500,/0/default.jpg)
The findings and the successful model of international collaboration have already spurred new studies. There are many questions still to address in the growing ENIGMA-OCD dataset. This has not only resulted in important contributions to the literature on brain alterations in OCD, but has also stimulated international collaboration and sharing of OCD imaging data from sites across the globe. Task-based fMRI analyses will be possible in the near future.ĮNIGMA-OCD has brought together OCD experts from all over the world to re-analyze historical MRI data using meta- and mega-analyses. New data pipelines are currently running, focusing on thalamus and cerebellum segmentations, voxel-based morphometry, and resting state fMRI data. An overview of the first 5 years of ENIGMA-OCD is recently published in the special issue on ENIGMA ( van den Heuvel et al. 2020 Transl Psych) and diffusion imaging ( Piras et al.
![van der heuvel human brain mapping diffusion van der heuvel human brain mapping diffusion](https://iiif.elifesciences.org/lax/60136%2Felife-60136-fig6-v2.tif/full/full/0/default.jpg)
Additional work is done (and still ongoing) employing machine learning techniques ( Bruin et al. 2020 Biol Psychiatry) in children, adolescents and adults with OCD, also including the study on the commonalities and distinctions across different neurodevelopment disorders ( Boedhoe et al. 2020 Brain), and brain lateralization ( Kong et al. 2018 Am J Psych), structural connectivity ( Yun et al. 2017 Am J Psych), cortical thickness ( Boedhoe et al. Initial work has focused on studies of subcortical volume ( Boedhoe et al. ENIGMA’s OCD working group currently consists of 47 samples from 34 institutes in 15 countries on 5 continents, with a total sample of 2,323 OCD patients and 2,325 healthy controls.